Water → HCID 86749910, compound

Participants

Reaction Steps

To the solution of 2.54 g of the compound (15) obtained in Example 15 in 6 ml of tetrahydrofuran, 6 ml of a 1M solution of tetrabutylammoniumfluoride-tetrahydrofuran was added dropwise. The mixture was stirred for one hour at room temperature. Water was added to the reaction solution, and the mixture was extracted with chloroform, the organic layer was dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The resulting residue was purified by silica gel column chromatography, and 580 mg (yield: 28.3 of the title compound (16) and 510 mg (yield 24.9%) of the title compound (17) were obtained from the fraction of ethyl acetate-hexane (4:1).

Provenance & Evidence