HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 864523Generated: October 31, 2026
Dimethylformamide → ethyl 4,6-dichloro-3-formyl-1H-indole-2-carboxylate
https://huagongshe.com/reaction/864523
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | ethyl 4,6-dichloro-1H-indole-2-carboxylate | HCID 2736407 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | ethyl 4,6-dichloro-3-formyl-1H-indole-2-carboxylate | HCID 2794948 | — |
Reaction Steps
Combine 2-carboethoxy-4,6-dichloroindole (10.0 g, 0.039 mol), and dimethylformamide (4.5 mL, 0.057 mol) in dichloroethane (20 mL). Add phosphoryl chloride (8.9 g, 0.058 mmol). Heat to 80° C. After 18 hours, cool the reaction mixture to ambient temperature and combine with aqueous 1M sodium acetate solution and stir. After 18 hours, filter, rinse with water, and dry to give 3-formyl-2-carboethoxy-4,6-dichloroindole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05563157 |
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| Source dataset | uspto-grants-1996_10 |
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| ORD ID | ord-51a6aabf800c4a3dadbf46084a29b257 |
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| Source note | uspto-grants-1996_10 |
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