Hydrogen chloride-ethyl acetate → HCID 22113017, compound

HRID 864604Notes

Reaction equation

HRID 864604 reaction equation
C(OC([N:8]([C:21]1[CH:22]=[CH:23][CH:24]=[C:25]2[C:30]=1[N:29]=[C:28]([CH3:31])[CH:27]=[CH:26]2)[CH2:9][C:10]1[C:15]([Cl:16])=[CH:14][CH:13]=[C:12]([N+:17]([O-:19])=[O:18])[C:11]=1[Cl:20])=O)(C)(C)C.C(OCC)(=O)C.[ClH:38]>>[ClH:16].[ClH:38].[Cl:20][C:11]1[C:12]([N+:17]([O-:19])=[O:18])=[CH:13][CH:14]=[C:15]([Cl:16])[C:10]=1[CH2:9][NH:8][C:21]1[CH:22]=[CH:23][CH:24]=[C:25]2[C:30]=1[N:29]=[C:28]([CH3:31])[CH:27]=[CH:26]2

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 22113088HCID 22113088, compound

Product 1

HCID 22113017HCID 22113017, compound

Procedure

8-[N-tert-Butoxycarbonyl-N-(2,6-dichloro-3-nitrobenzyl)amino]-2-methylquinoline (100 mg) was treated with 4M hydrogen chloride -ethyl acetate (2 ml) at ambient temperature for 40 minutes. The precipitate was collected by vacuum filtration and washed with ethyl acetate to give 8-[(2,6-dichloro-3-nitrobenzyl)amino]-2-methylquinoline dihydrochloride (88 mg) as pale yellow crystals.

Workup

  1. filtrationThe precipitate was collected by vacuum filtration
  2. washwashed with ethyl acetate

Sources & evidence

ORD record
ord-739ebf6c7f2146b69dead4dde7f83e44
Source dataset
uspto-grants-1996_10
Patent number
US05563162

Reaction notes

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