2-(Dimethylamino)ethanol → Isopropyl 2-dimethylaminoethyl carbonate

HRID 864666Notes

Reaction equation

HRID 864666 reaction equation
[CH3:1][N:2]([CH2:4][CH2:5][OH:6])[CH3:3].[C:7](=O)([O:10][CH:11]([CH3:13])[CH3:12])[O:8]C>CO>[C:7](=[O:8])([O:6][CH2:5][CH2:4][N:2]([CH3:3])[CH3:1])[O:10][CH:11]([CH3:13])[CH3:12]

Participants

4

Reactant 2

HCID 79022-(Dimethylamino)ethanolHCID 7021530Methyl isopropyl carbonate

Product 1

HCID 19419881Isopropyl 2-dimethylaminoethyl carbonate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

reacting 2-(N,N-dimethylamino)ethanol with the methyl isopropyl carbonate formed in step i) in the presence of a transesterification catalyst to form isopropyl 2-dimethylaminoethyl carbonate and methanol, under such conditions that the 2-(N,N-dimethylamino)ethanol also reacts with the diisopropyl carbonate formed in step i) to form more isopropyl 2-dimethylaminoethyl carbonate,

Sources & evidence

ORD record
ord-dea318db98f74081977ee6eb793bba9f
Source dataset
uspto-grants-1996_10
Patent number
US05563288

Reaction notes

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