2-(Dimethylamino)ethanol → 2-(Dimethylamino)ethanol

HRID 864668Notes

Reaction equation

HRID 864668 reaction equation
[CH3:1][N:2]([CH2:4][CH2:5][OH:6])[CH3:3].[C:7](=O)([O:10][CH:11]([CH3:13])[CH3:12])[O:8]C>CO>[C:7](=[O:8])([O:6][CH2:5][CH2:4][N:2]([CH3:3])[CH3:1])[O:10][CH:11]([CH3:13])[CH3:12].[CH3:1][N:2]([CH2:4][CH2:5][OH:6])[CH3:3]

Participants

5

Reactant 2

HCID 79022-(Dimethylamino)ethanolHCID 7021530Methyl isopropyl carbonate

Product 2

HCID 79022-(Dimethylamino)ethanolHCID 19419881Isopropyl 2-dimethylaminoethyl carbonate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a preferred embodiment of the one-step process, bis[2-(N,N-dimethylamino)ethyl]carbonate is produced by the process comprising the step of reacting 2-(N,N-dimethylamino)ethanol with methyl isopropyl carbonate in the presence of a transesterification catalyst to form isopropyl 2-dimethylaminoethyl carbonate and methanol, wherein the 2-(N,N-dimethylamino)ethanol reacts with the isopropyl 2-dimethylaminoethyl carbonate to form bis[2-(N,N-dimethylamino)ethyl] carbonate and isopropanol, under conditions such that the methanol and isopropanol are removed continuously by distillation so that the reactions proceed toward formation of bis[2-(N,N-dimethylamino)ethyl] carbonate.

Sources & evidence

ORD record
ord-36a7a12655f24070b944c915e76031ba
Source dataset
uspto-grants-1996_10
Patent number
US05563288

Reaction notes

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