Ethyl 2-(4-nitro-1H-imidazole-1-yl)octanoate → ethyl 2-(4-amino-1H-imidazol-1-yl)octanoate

Participants

Reaction Steps

A mixture of 5.9 g of 4-nitro-α-hexyl-1H-imidazole-1-acetic acid ethyl ester, 3 g of palladium-on-carbon and 150 ml of absolute alcohol were subjected to catalytic hydrogenation. Both theoretical and actual hydrogen uptake was 73 pounds. The catalyst was removed by filtration and the filtrate concentrated in vacuo to provide 5.3 g of the desired title intermediate which was used directly.

Provenance & Evidence