HCID 86749921, compound → HCID 54511231, compound

HRID 864681Notes

Reaction equation

HRID 864681 reaction equation
[CH2:1]([O:3][C:4](=[O:34])[CH2:5][N:6]1[CH:10]=[C:9]([NH:11][C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-])=O)[C:15]=2[C:23]([O:25][CH2:26][CH3:27])=[O:24])=[O:13])[N:8]=[C:7]1CCCCCC)[CH3:2]>[Pd]>[CH2:1]([O:3][C:4](=[O:34])[CH:5]([CH2:18][CH2:19][CH2:14][CH2:15][CH2:16][CH3:17])[N:6]1[CH:10]=[C:9]([NH:11][C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([NH2:20])[C:15]=2[C:23]([O:25][CH2:26][CH3:27])=[O:24])=[O:13])[N:8]=[CH:7]1)[CH3:2]

Participants

3

Reactant 1

HCID 86749921HCID 86749921, compound

Product 1

HCID 54511231HCID 54511231, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of 5.1 g of -hexyl-4-{[(3-nitro-2ethoxycarbonylphenyl)carbonyl]amino}imidazole-1-acetic acid ethyl ester and 2.1 g of 5% palladium-on-carbon were hydrogenated in the presence of 150 ml of methanol until consumption of hydrogen ceased. The catalyst was removed by filtration and the filtrate concentrated in vacuo to provide 4.7 g of the desired subtitled intermediate. NMR.

Workup

  1. customwere hydrogenated in the presence of 150 ml of methanol until consumption of hydrogen
  2. customThe catalyst was removed by filtration
  3. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-614a441faa104fd9afc2c5dfa5472caa
Source dataset
uspto-grants-1996_10
Patent number
US05563278

Reaction notes

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