4,4,4-Trifluoro-3-methyl-2-butenoic acid → 4,4,4-Trifluoro-3-methylbutanoic acid

Participants

Reaction Conditions

Reaction Steps

In an atmosphere of argon, 12 mg (14.1×10-3 mmol) of Ru(OAc)2 [(S)-(-)-OcH-binap] complex and 434.7 mg (2.82 mmol) of 3-trifluoromethylcrotonic acid were dissolved in 14 ml of methanol, and the resulting solution was put into a 100 ml capacity autoclave and stirred at 25° C. for 63 hours under a hydrogen pressure of 100 atm. The reaction solution was concentrated and then subjected to distillation to obtain 376 mg of (-)-3-trifluoromethylbutanoic acid with a yield of 85%.

Provenance & Evidence