反应详情

温度

80 °C

A mixture of 3,5-dichloro-2-[2-(dimethylamino)ethoxy)-pyridine-4-carboxylic acid hydrochloride (2.65 g, 0.0084 mol), cesium carbonate (4.1 g, 0.013 mol), tetrabutylammonium bromide (1.0 g, 0.003 mol) and DMF (25 ml) was stirred for 10 minutes, then 2-chloromethyl-4-isopropyl-6-methoxysaccharin (2.4 g, 0.0084 mol) was added. The mixture was heated to 80° C. and stirred for 1 hour. The solvent was removed in vacuo and the residue was partitioned between water/methylene chloride. The organic layer was separated, washed with water, dried over anhydrous MgSO4 and concentrated in vacuo. The residue was dissolved in ethyl acetate and filtered through a plug of silica. Ethereal HCl was added to the filtrate and the solvent was removed in vacuo. The residue was washed with ether (50 ml), treated with saturated NaHCO3 and extracted with methylene chloride. The solvent was removed in vacuo, the residue was triturated with methanol and an off-white solid was collected by filtration. The product was dried in high vacuum to afford 0.096 g (2.1%) of 4-isopropyl-6-methoxy-2-saccharinylmethyl 3,5-dichloro-2-[2-(dimethylamino)ethoxy]pyridine-4-carboxylate, m.p. 155°-160° C. (dec).

1. stirringstirred for 1 hour
2. customThe solvent was removed in vacuo
3. customthe residue was partitioned between water/methylene chloride
4. customThe organic layer was separated
5. washwashed with water
6. dry with materialdried over anhydrous MgSO4
7. concentrationconcentrated in vacuo
8. dissolutionThe residue was dissolved in ethyl acetate
9. filtrationfiltered through a plug of silica
10. additionEthereal HCl was added to the filtrate
11. customthe solvent was removed in vacuo
12. washThe residue was washed with ether (50 ml)
13. additiontreated with saturated NaHCO3
14. extractionextracted with methylene chloride
15. customThe solvent was removed in vacuo
16. customthe residue was triturated with methanol
17. filtrationan off-white solid was collected by filtration
18. customThe product was dried in high vacuum