Sodium Hydroxide → HCID 23662256, compound

HRID 864823Notes

Reaction equation

HRID 864823 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]([C:16]3[CH:26]=[CH:25][C:19]([C:20]([O:22]CC)=[O:21])=[CH:18][CH:17]=3)=[O:15])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[OH-].[Na+:28]>CO>[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:8][CH2:9][N:10]([CH2:13][C:14]([C:16]3[CH:26]=[CH:25][C:19]([C:20]([O-:22])=[O:21])=[CH:18][CH:17]=3)=[O:15])[CH2:11][CH2:12]2)=[CH:3][CH:2]=1.[Na+:28]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18918323HCID 18918323, compound

Product 1

HCID 23662256HCID 23662256, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A stirred suspension of the product of Example 131 (353 mg) in methanol (5 ml) was treated with a 1 molar sodium hydroxide solution (3 ml). After 2 hours, the cream coloured solid was collected, washed with a little methanol and dried to give the title compound, 240 mg, m.p. >300° C.; NMR (d6DMSO) δ8.15 (2H, d) 8.05 (4H, t, AB pattern), 6.85 (2H, d), 3.97 (2H, s), 3.38 (4H, t), 2.65 (4H, t), m/e 348 (M+H)+ ; calculated for C18H18N3NaO3. 0.25H2O: C, 61.4; H, 5.3; N, 11.9. found: C, 61.3; H, 5.2; N, 11.7%.

Workup

  1. customwas collected
  2. washwashed with a little methanol
  3. customdried

Sources & evidence

ORD record
ord-4ff2f7c654dd4fceaf0f78a0367e4fa0
Source dataset
uspto-grants-1996_10
Patent number
US05563141

Reaction notes

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