Triethylamine → HCID 86638743, compound

Participants

Reaction Steps

A solution of methanesulphonyl chloride (0.85 ml) in dichloromethane (20 ml) was added dropwise to a stirred, ice-cooled solution of triethylamine (1.55 ml) and the product of step (i) (2.64 g) in dichloromethane (50 ml). After stirring for 3 hours the reaction mixture was washed with water (3x) and brine, dried (PS paper) and evaporated in vacuo to yield N-benzyloxycarbonylpiperidin-4-ylethanol mesylate as a colourless paste (3.4 g) NMR (d6DMSO): δ0.9-1.2 (2H,m); 1.5-1.8 (5H,m);2.6-2.9 (2H,m); 4.0 (2H,d);4.25 (2H,t);4.4 (3H,s); 5.1 (2H,s); 7.35 (5H,m); m/e 342 (M+H)+.

Provenance & Evidence