HCID 53828832, compound → HCID 53661719, compound

HRID 865002Notes

Reaction equation

HRID 865002 reaction equation
C([O:8][CH2:9][C:10]1[C:15]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[C:29]([O:31][CH3:32])=[O:30])=[CH:19][CH:18]=2)=[C:14]([CH2:33][CH2:34][CH2:35][CH3:36])[N:13]=[C:12]([CH3:37])[N:11]=1)C1C=CC=CC=1>CCO.[Pd]>[CH2:33]([C:14]1[C:15]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[C:29]([O:31][CH3:32])=[O:30])=[CH:19][CH:18]=2)=[C:10]([CH2:9][OH:8])[N:11]=[C:12]([CH3:37])[N:13]=1)[CH2:34][CH2:35][CH3:36]

Participants

4

Reactant 1

HCID 53828832HCID 53828832, compound

Product 1

HCID 53661719HCID 53661719, compoundYield 95%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution containing 0.5 g of 4-benzyloxymethyl-6-butyl -2-methyl-5-[(2'-methoxycarbonylbiphenyl-4-yl) methyl]pyrimidine in 50 ml of EtOH was hydrogenated in presence of 0.1 g of 10% palladium on charcoal at atmospheric pressure and room temperature. After the theoretical hydrogen absorption the reaction mixture was filtered on Celite® and the solvent was evaporated obtaining 0.38 g of a clear oil, which was directly used without further purification (yield 95%).

Workup

  1. customAfter the theoretical hydrogen absorption the reaction mixture
  2. filtrationwas filtered on Celite®
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-2d5d31d22eec42bb838857c117fa2ce7
Source dataset
uspto-grants-1996_10
Patent number
US05565464

Reaction notes

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