2-bromo-5-methoxy-3,4-dihydronaphthalen-1(2H)-one → 2-(4-Imidazolylmethyl)-6-methoxy-4,5-dihydronaphtho[1,2-d]thiazole

HRID 865101Notes

Reaction equation

HRID 865101 reaction equation
Br[CH:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[O:12][CH3:13])[C:3]1=O.Cl.[NH:16]1[CH:20]=[C:19]([CH2:21][C:22]([NH2:24])=[S:23])[N:18]=[CH:17]1>>[NH:16]1[CH:20]=[C:19]([CH2:21][C:22]2[S:23][C:2]3[CH2:11][CH2:10][C:9]4[C:4](=[CH:5][CH:6]=[CH:7][C:8]=4[O:12][CH3:13])[C:3]=3[N:24]=2)[N:18]=[CH:17]1

Participants

3

Reactant 2

HCID 189411012-bromo-5-methoxy-3,4-dihydronaphthalen-1(2H)-oneHCID 178479561HCID 178479561, compound

Product 1

HCID 1784883132-(4-Imidazolylmethyl)-6-methoxy-4,5-dihydronaphtho[1,2-d]thiazole

Procedure

Starting compounds: 2-bromo-5-methoxy-1-tetralone, 4-imidazolylthioacetamide hydrochloride

Sources & evidence

ORD record
ord-728fc087a941415f9efaa8a692b206ea
Source dataset
uspto-grants-1996_10
Patent number
US05565479

Reaction notes

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