反应详情

5.0 g of Raney nickel (wet) was added to a solution of 0.52 g of.2-(4-imidazolylmethyl)-8-nitro-4,5-dihydronaphtho[1,2-d]thiazole obtained in Example 23 in 1,4-dioxane (40 ml)-methanol (20 ml), and the mixture was stirred for 2 hours in an atmosphere of hydrogen (1 atm). After filtration of insoluble matter, the solvent was evaporated from the filtrate, and the residue was mixed with ethyl acetate to effect crystallization. The resultant crude crystals were washed with hot ethyl acetate to afford 0.27 g (57%) of 8-amino-2-(4-imidazolylmethyl)-4,5-dihydronaphtho[1,2-d]thiazole.

1. filtrationAfter filtration of insoluble matter
2. customthe solvent was evaporated from the filtrate
3. additionthe residue was mixed with ethyl acetate
4. customcrystallization
5. washThe resultant crude crystals were washed with hot ethyl acetate