反应详情

3.1 g (10 mmol) of N-[3-methyl-2-(4-methyl-benzoyl)benzofuran-6-yl]-acetamide were suspended in 40 ml methanol. 20 ml 2.6N HCl were added with stirring. The reaction mixture was heated to reflux. After 1 hour a clear solution was obtained. After 3 hours reflux the solution was cooled to room temperature and ethylacetate was added. The organic layer was washed once with NaOH-solution, two times with water, dried over Na4SO4 and concentrated in vacuo. The residue was further purified by crystallisation.

1. temperatureThe reaction mixture was heated to reflux
2. customAfter 1 hour a clear solution was obtained
3. temperatureAfter 3 hours reflux the solution
4. washThe organic layer was washed once with NaOH-solution, two times with water
5. dry with materialdried over Na4SO4
6. concentrationconcentrated in vacuo
7. customThe residue was further purified by crystallisation