Trifluoroacetic anhydride → HCID 15817308, compound

Participants

Reaction Steps

The acid from Step 5 (7.63 g, 33 mmol) was dissolved in trifluoroacetic acid (12 mL), treated with trifluoroacetic anhydride (4 mL) and stirred at room temperature (8 minutes). The reaction was poured into 10% Na2CO3 (50 mL) and extracted with ethyl acetate, washed with brine, dried over MgSO4 and concentrated in vacuo to give 8-fluoro-7-methoxyisothiochroman-4-one (5.42 g, 77%) as a brown solid: mp 85°-92° C.; 1H NMR (CDCl3) 300 MHz 7.83 (d, J=8.9 Hz, 1H) 7.19 (t, J=8.5 Hz, 1H) 4.01 (s, 2H) 3.98 (s, 3H) 3.55 (s, 2H); 19F NMR (CDCl3) 300 MHz -141.24 (m).

Provenance & Evidence