4-Chlorophenyl Isocyanate → HCID 19417843, compound

Participants

Reaction Steps

The 3-(dimethylamino)benzenesulfonamide was dissolved in acetone (9.1 ml) to which was added 9.3 ml of 1N sodium hydroxide. To this mixture was added 4-chlorophenylisocyanate (1.43 g, 9.3 mmoles) dissolved in 9.1 ml of acetone. This mixture was stirred for 45 minutes at room temperature and then filtered. The filtrate was acidified using 1N hydrochloric acid (9.3 ml) and stirred for 2 hours, resulting in a precipitate. The solid was collected, washed thrice with water, and recrystallized using heated toluene (150 ml) and ethyl acetate (25 ml), followed by filtration and cooling.

Provenance & Evidence