Morpholine → 4-(Morpholin-4-yl)benzene-1-sulfonamide

HRID 865315Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 865315
F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>C(Cl)Cl>[N:12]1([C:2]2[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

Komponenten

4

Edukt 2

HCID 8083MorpholineHCID 1202314-Fluorobenzenesulfonamide

Produkt 1

HCID 7354354-(Morpholin-4-yl)benzene-1-sulfonamideAusbeute 73,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

4-Fluorobenzenesulfonamide (5.50 g, 31.4 mmoles) was dissolved in 100 ml of morpholine (99.6 g, 1.14 moles) and was refluxed for 3 days. The solvent was removed by evaporation, yielding an orange oil. Methylene chloride (100 ml) was added, causing the oil to solidify. The solid was collected by filtration, then heated in 100 ml of ethanol. After cooling, the solid was collected by filtration, yielding 5.59 g (73%) of 4-(4-morpholinyl)benzenesulfonamide as a white solid.

Aufarbeitung

  1. temperaturewas refluxed for 3 days
  2. customThe solvent was removed by evaporation
  3. customyielding an orange oil
  4. filtrationThe solid was collected by filtration
  5. temperatureheated in 100 ml of ethanol
  6. temperatureAfter cooling
  7. filtrationthe solid was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-be990128fcec4b8eb871bc1c515b7d07
Quelldatensatz
uspto-grants-1996_10
Patentnummer
US05565494

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