反应详情

4-Fluorobenzenesulfonamide (5.50 g, 31.4 mmoles) was dissolved in 100 ml of morpholine (99.6 g, 1.14 moles) and was refluxed for 3 days. The solvent was removed by evaporation, yielding an orange oil. Methylene chloride (100 ml) was added, causing the oil to solidify. The solid was collected by filtration, then heated in 100 ml of ethanol. After cooling, the solid was collected by filtration, yielding 5.59 g (73%) of 4-(4-morpholinyl)benzenesulfonamide as a white solid.

1. temperaturewas refluxed for 3 days
2. customThe solvent was removed by evaporation
3. customyielding an orange oil
4. filtrationThe solid was collected by filtration
5. temperatureheated in 100 ml of ethanol
6. temperatureAfter cooling
7. filtrationthe solid was collected by filtration