Morpholine → 4-(Morpholin-4-yl)benzene-1-sulfonamide

HRID 865315ノート

反応式

HRID 865315 の反応式
F[C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>C(Cl)Cl>[N:12]1([C:2]2[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=2)[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

参加物

4

反応物 2

HCID 8083MorpholineHCID 1202314-Fluorobenzenesulfonamide

生成物 1

HCID 7354354-(Morpholin-4-yl)benzene-1-sulfonamide収率 73.5%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

4-Fluorobenzenesulfonamide (5.50 g, 31.4 mmoles) was dissolved in 100 ml of morpholine (99.6 g, 1.14 moles) and was refluxed for 3 days. The solvent was removed by evaporation, yielding an orange oil. Methylene chloride (100 ml) was added, causing the oil to solidify. The solid was collected by filtration, then heated in 100 ml of ethanol. After cooling, the solid was collected by filtration, yielding 5.59 g (73%) of 4-(4-morpholinyl)benzenesulfonamide as a white solid.

後処理

  1. temperaturewas refluxed for 3 days
  2. customThe solvent was removed by evaporation
  3. customyielding an orange oil
  4. filtrationThe solid was collected by filtration
  5. temperatureheated in 100 ml of ethanol
  6. temperatureAfter cooling
  7. filtrationthe solid was collected by filtration

出典と根拠

ORDレコード
ord-be990128fcec4b8eb871bc1c515b7d07
出典データセット
uspto-grants-1996_10
特許番号
US05565494

反応ノート

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