2,5 Dibromotoluene → 1,4-Dibromo-2-(bromomethyl)benzene

Temperature

150 °C

33 g (0.1 mole) 2,5-dibromo toluene is placed in a 100 ml three-necked flask, fitted with a reflux condenser, a sealed mechanical stirrer, and a separatory funnel with the stem reaching nearly to the bottom of the flask. The flask is illuminated with two 300-watt tungsten lamps during the reaction. The flask is heated in an oil bath to 150° C., and 18.4 g (5.9 ml, 0.115 mole) bromine is added over two hours. The mixture is stirred for an additional 10 minutes, and the contents, while still liquid, are poured into a 500 ml round-bottom flask containing 300 ml of hot light petroleum ether and 2 g decolorizing carbon. A reflux condenser is attached, and the mixture is heated to reflux until the material dissolves, then rapidly filtered through a pre-heated Buchner funnel. The filtrate is cooled and washed with cold light petroleum.

1. customfitted with a reflux condenser, a sealed mechanical stirrer, and a separatory funnel with the stem
2. additionthe contents, while still liquid, are poured into a 500 ml round-bottom flask
3. customA reflux condenser is attached
4. temperaturethe mixture is heated
5. temperatureto reflux until the material
6. dissolutiondissolves
7. filtrationrapidly filtered through a pre-heated Buchner funnel
8. temperatureThe filtrate is cooled
9. washwashed with cold light petroleum

ORD record

ord-06440eaa704a44ab983435d709b78aca

Source dataset

uspto-grants-1996_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05565543