反应详情

温度

45 °C

Twenty-five milliliters of a 5% aqueous sodium hydroxide solution, 3.84 g of 5-(3-cyclohexene-1-yl)methylenehydantoin and 0.43 g of wet 10% palladium on carbon (moisture 50%) were placed in a reactor equipped with a mechanical stirrer and a reflux condenser, and the mixture was reduced while stirring at 45° C. under a hydrogen pressure of 3.5 kg/cm2. After 9 hours, the palladium on carbon was removed by filtration, and the pH of the filtrate was adjusted to about 3 by addition of 1N hydrochloric acid, upon which white crystals were obtained. These were collected by filtration and washed with water, and then dried under reduced pressure at 60° C. overnight to obtain 3.43 g of 5-cyclohexylmethylhydantoin. The yield was 87.4%.

1. customequipped with a mechanical stirrer and a reflux condenser
2. customthe palladium on carbon was removed by filtration
3. additionthe pH of the filtrate was adjusted to about 3 by addition of 1N hydrochloric acid, upon which white crystals
4. customwere obtained
5. filtrationThese were collected by filtration
6. washwashed with water
7. customdried under reduced pressure at 60° C. overnight