Diethyl Ether → Ethyl 3-(acetylsulfanyl)-2-methylpropanoate

HRID 865446Notes

Reaction equation

HRID 865446 reaction equation
[CH3:1][C:2](=[CH2:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[S:9]1C=CC=C1CC(O)=O.[CH3:18][CH2:19][O:20]CC>>[C:19]([S:9][CH2:8][CH:2]([CH3:1])[C:3]([O:5][CH2:6][CH3:7])=[O:4])(=[O:20])[CH3:18]

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 7343Ethyl MethacrylateHCID 159702-Thiopheneacetic acid

Product 1

HCID 15289598Ethyl 3-(acetylsulfanyl)-2-methylpropanoate

Conditions

Temperature
65 °C

Procedure

Ethyl 2-methylpropenoate (39 mmol) was diluted with 5.6 mL (78 mmol) of thiolacetic acid and stirred at 65° C. for 36 h. The mixture was then diluted with ether, washed with water and the organic phase was dried with Na2SO4. Evaporation to dryness yielded the title material as an orange oil which was used as such for the next step.

Workup

  1. washwashed with water
  2. dry with materialthe organic phase was dried with Na2SO4
  3. customEvaporation to dryness

Sources & evidence

ORD record
ord-b3d303635d0d46feaf847ea255077e41
Source dataset
uspto-grants-1996_10
Patent number
US05565473

Reaction notes

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