化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → Methyl alpha-(4-tert-butyldimethylsilyloxy-methyl-2-n-propylphenoxy)-3,4-methylenedioxyphenylacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 反応物 | Methyl alpha-(4-hydroxymethyl-2-n-propyl-phenoxy)-3,4-methylenedioxyphenylacetate | HCID 19080423 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Methyl alpha-(4-tert-butyldimethylsilyloxy-methyl-2-n-propylphenoxy)-3,4-methylenedioxyphenylacetate | HCID 131719617 | 97% |
反応手順
To a solution of 2.50 g (6.98 mmol) of the product of Step A dissolved in 20 mL of dichloromethane was added 1.95 mL (14.0 mmol) of triethylamine, 1.26 g (8.38 mmol) of tert-butyldimethylchlorosilane, 85 mg (0.1 eq) of 4-dimethylaminopyridine and the reaction mixture was stirred at room temperature for 30 minutes under a nitrogen atmosphere. The reaction was then diluted with 100 mL EtOAc, washed with water, 1.0 N HCl, saturated aqueous NaHCO3, saturated NaCl, dried (MgSO4), filtered and evaporated in vacuo to afford 3.20 g (97%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05565485 |
| 出典データセット | uspto-grants-1996_10 |
| ORD ID | ord-97234efc43434420864aea725558d053 |
| 出典メモ | uspto-grants-1996_10 |