HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl alpha-(2-n-propyl-4-cyanophenoxy)-3,4-methylenedioxyphenylacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Chloroform methanol ammonium hydroxide | HCID 21873181 | — |
| Reactant | Methyl alpha-(2-n-propyl-4-cyanophenoxy)-3,4-methylenedioxyphenylacetate | HCID 22912470 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl alpha-(2-n-propyl-4-cyanophenoxy)-3,4-methylenedioxyphenylacetic acid | HCID 22912495 | — |
Reaction Steps
To a solution of 3.5 g (8.64 mmol) of the product of Step C in 30 mL of methanol was added 2.07 mL (10.37 mmol) of 5.0N aqueous sodium hydroxide solution. After stirring overnight, TLC analysis (80:15:1 chloroform/methanol/ammonium hydroxide) indicated that the saponification was complete. The reaction mixture was acidified to pH 3 with 6N aqueous HCl and concentrated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05565485 |
| Source dataset | uspto-grants-1996_10 |
| ORD ID | ord-3199e72a622e4fb095f6eed15966f876 |
| Source note | uspto-grants-1996_10 |