反应详情

温度

40 °C

A mechanically stirred mixture of 2-chloro-5-nitropyridine (56.25 g, 0.355 mol) and absolute EtOH (960 ml), under nitrogen was treated, during 15 minutes with 25% aqueous trimethylamine (217 g). The mixture warmed to 40° C. and a thick yellow precipitate formed; it was warmed to 80° C. during 1 hour, cooled to ambient temperature and filtered. The solid was washed with cold 20% H2O-EtOH and dried to give 53.2 g of the titled product, m.p. 151°-152° C.

1. customa thick yellow precipitate formed
2. temperatureit was warmed to 80° C. during 1 hour
3. temperaturecooled to ambient temperature
4. filtrationfiltered
5. washThe solid was washed with cold 20% H2O-EtOH
6. customdried