Diethyl Ether → HCID 178512256, compound

Participants

Reaction Steps

A stirred mixture of 5-amino-2-chloropyridine (1.3 g, 0.01 mol) and diphenylcyanocarbonimidate (2.4 g, 0.01 mol) in 15 ml of ethylene glycoldimethyl ether (DME), under nitrogen, was kept at 60° C. for 24 hours and at 85° C. for 6 hours when it was allowed to cool to room temperature. The solvent was removed in vacuo and the residue was heated to a melt at 120° C., under nitrogen, for 1 hour to complete the reaction as shown by TLC (5% MeOH/CHCl3). This was allowed to cool and was triturated with Et2O to give a solid that was collected by filtration. The solid was washed with Et2O to give 2.61 g of the titled product.

Provenance & Evidence