Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Iodoethane | HCID 6340 | — |
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | 3-(3-Trifluoromethylphenyl)propanoic acid | HCID 2777683 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 22595510 | HCID 22595510 | — |
Reaction Steps
1 eq. of 3-(3-trifluoromethylphenyl)propionic acid was converted, in THF and at -78° C., into the dianion using 2 eq. of LDA (stirring for 30 min. at -78° C., then 30 min. at RT). 2 eq. of ethyl iodide were then added at -78° C. and the mixture was subsequently stirred at RT. Acidic working-up using 2N HCl and purification by chromatography yielded 2-ethyl-3-(3-trifluoromethylphenyl)-propionic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05567734 |
|---|
| Source dataset | uspto-grants-1996_10 |
|---|
| ORD ID | ord-7007460e7b4b45139c9d4bdbcafe1b49 |
|---|
| Source note | uspto-grants-1996_10 |
|---|
