4-Toluenesulfonyl chloride → 2-(2-(2-Methoxyethoxy)ethoxy)ethyl 4-methylbenzenesulfonate

Participants

Reaction Steps

Compound 22 was prepared using the method described for the synthesis of compound 18. The reagents used were as follows, p-toluene sulphonyl chloride (170.4 g, 0.894 mol.), pyridine (400 ml) and 2-(2'-(2"-methoxy ethoxy)ethoxy)ethanol (148.7 g, 0.907 mol.) (Aldrich). The final product was a pale yellow liquid (122 g, 42%): 1H-NMR (CDCl3), d (ppm) 7.3-7.7 (m, 4H aromatic), 3.3-4.2 (m, 12H) 3.35 (s, 3H), 2.4 (s, 3H). Mass spectroscopy, m/e: 318 M+.

Provenance & Evidence