Hydrochloric Acid → HCID 53827300, compound

Participants

Reaction Steps

3-Aminopropyl solketal (2.43 g 12.8 mmole) was dissolved in THF (30 ml) and aqueous hydrochloric acid (1M, 30 ml) was added. After 1 hour at room temperature TLC (acetonitrile/methanol/triethlyamine 80/18/2) indicated that all starting material Rf 0.33 had been hydrolyzed to the diol Rf ca.0.0 (detection by ninhydrin spray). THF was evaporated in vacuo and the aqueous residue was applied to a Dowex 50 ion exchange column (100 ml, H form). The resin was washed with water to remove all Cl ion and the desired amine was eluted with aqueous ammonia. The ammonia solution was evaporated to remove all volatile material and the aqueous residue used for subsequent reactions without further purification.

Provenance & Evidence