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HRID865828

反应详情

EQUATION

反应方程式

HRID 865828 的结构方程式

REACTANTS

反应物

2
结构：CCC[C@@H]1C[C@@H](C(=O)N[C@@H]([C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)[C@@H](C)O)N(C)C1.Cl
HCID64710

Lincomycin hydrochloride

C18H35ClN2O6S

结构：O=C(O)/C=C/CCCCCCCCC(=O)O
HCID5283028

Traumatic acid

C12H20O4

PRODUCTS

生成物

1
结构：CCC[C@@H]1C[C@@H](C(=O)N[C@@H]([C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)[C@@H](C)O)N(C)C1.O=C([O-])/C=C/CCCCCCCCC(=O)[O-]
HCID131719628

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

2 次

CONDITIONS

反应条件

温度
4 °C

PROCEDURE

实验过程

2.28 g of trans-traumatic acid (10 mmol) are suspended in 100 ml of water cooled to 4° C. A solution of 8.86 g of lincomycin hydrochloride (20 mmol) in 100 ml water is eluted through a column cooled to 4° C. containing 35 ml of [OH--] Dowex 1×8 resin. The eluate free from chlorides is collected in the form of a suspension of traumatic acid kept under continuous stirring at 4° C. The resulting solution is frozen and lyophilized. The reaction yield is 10.1 g of dry product.

WORKUP

后处理

  1. temperaturecooled to 4° C.
  2. additioncontaining 35 ml of [OH--] Dowex 1×8 resin
  3. customThe eluate free from chlorides is collected in the form of a suspension of traumatic acid
  4. temperatureThe resulting solution is frozen
  5. customThe reaction yield is 10.1 g of dry product