反应详情

温度

4 °C

2.28 g of trans-traumatic acid (10 mmol) are suspended in 100 ml of water/ethanol 2:1 mixture at 4° C. 14.7 g of erythromycin free base (20 mmol) are added and the resulting mixture is kept under stirring at 4° C. for 3 hours and then heated to 25° C. overnight. 200 ml water ape then added. The mixture is concentrated under vacuum to a volume of about 100 ml and cooled to 4° C.

1. customat 4° C
2. temperatureheated to 25° C. overnight
3. concentrationThe mixture is concentrated under vacuum to a volume of about 100 ml
4. temperaturecooled to 4° C.