Ammonia → HCID 135744107, compound

Participants

Reaction Steps

Ammonia gas was passed through a solution of phenylmethyl[2-[(2-acetylphenyl)amino]-1-[(1-methylethyl)thio]-2-oxoethyl]carbamate (14.74 g) in dry THF (250 ml) at 0° for 0.5 h. Mercury (II) chloride (10.00 g) was added and the mixture was rapidly stirred for 6 h whilst continuing to pass ammonia gas through the mixture. The mixture was filtered through hyflo and the solvent removed from the filtrate by evaporation in vacuo. The residue was treated with acetic acid (290 ml) and sodium acetate (13.35 g) and the resulting mixture stirred at 23° for 18 h. The solvent was evaporated in vacuo and the residue was purified by chromatography. Elution with EA gave the title compound (5.70 g).

Provenance & Evidence