3-Isocyanatobenzonitrile → HCID 23373681, compound

Participants

Reaction Steps

3-Cyanophenyl isocyanate (278 mg) was added to a solution of 3-amino-2,3-dihydro-1-(3,3,-dimethyl-2-oxo-butyl)-5-methyl-2-oxo-1H-1,4-benzodiazepine (500 mg) in dry MeCN (13 ml) at 23° under nitrogen. After 30 min the resulting thick slurry was stirred with DE (5 ml) filtered and the filtercake washed with EA and DE then dried in vacuo at 50° to give the title compound (571 mg) as a white solid, m.p. 246°-7°

Provenance & Evidence