Hydrochloric Acid → HCID 67747011, compound

Participants

Reaction Steps

A solution of the (+)-2-{3-[3-(3-Methoxy-phenyl)-ureido]-5-morpholin-4-ylmethyl 2-oxo-2,3-dihydro-benzo [e][1,4]diazepin-1-yl}-N-methyl-N-phenyl-acetamide (200 mg) in dry DCM (20 ml) under nitrogen was treated with 1M hydrogen chloride in diethyl ether (0.77 ml) and the solution was stirred for 5 min. The solvent was removed in vacuo and the residue azeotroped with toluene (2×10 ml) to give the title compound (215 mg) as a pale straw coloured solid, m.p. 160°-170° dec.

Provenance & Evidence