4-Chlorobenzoyl chloride → HCID 131711131, compound

Participants

Reaction Steps

Ten grams of 2-[[[2-[3-(Dimethylamino)propoxy]-phenyl]methyl]amino]acetamide (see Example 2B) and 7.1 g of p-chlorobenzoyl chloride are reacted in 110 ml of chloroform as described in Example 1. The finely-divided, solid product separates at the end of the addition; crude yield, after standing for about 16 hours at room temperature, 10.2 g; melting point 195°-197° C dec, sintering at 175° C. Work-up of the mother liquor does not yield any additional product. Following crystallization (of 9.7 g) from 50 ml of warm methanol - 100 ml of ether, the material weighs 6.3 g; melting point 198°-200° C, dec, sintering at 175° C.

Provenance & Evidence