反应详情

Ethyl α-Bromo-4-chloro-o-toluate (26.4 g.) is added to a solution (10°) of sodium methoxide (5.4 g.) in 110 ml. of methanol. When the addition is complete, the mixture is refluxed for two hours, then cooled and concentrated in vacuo. The oily residue is partioned between ether-water. The ether layer is separated and dried. Removal of the drying agent and concentration of the filtrate in vacuo leaves 17.3 g. of a white solid. A sample of the product recrystallized from methanol had mp 44°-45°.

1. additionWhen the addition
2. temperaturethe mixture is refluxed for two hours
3. temperaturecooled
4. concentrationconcentrated in vacuo
5. customThe ether layer is separated
6. customdried
7. customRemoval of the drying agent and concentration of the filtrate in vacuo
8. customleaves 17.3 g
9. customA sample of the product recrystallized from methanol