Phenethylamine → HCID 178433302, compound

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Reaction Steps

A solution of N-cyano-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-S-methylisothiourea (2.69 g) and 2-phenylethylamine (7.2 g) in acetonitrile (50 ml) was heated under reflux for 24 hours. Following concentration and ether extraction to remove excess 2-phenylethylamine the crude product was chromatographed on a column of silica gel and eluted with ethyl acetate-isopropyl alcohol (4:1). Recrystallisation from ethanol-ether afforded the title compound (1.4 g) m.p. 135°-136°. (Found: C, 59.8; H, 6.8; N, 24.8; S, 9.4% C17H22N6S requires: C, 59.6; H, 6.5; N, 24.5; S, 9.4%).

Provenance & Evidence