Histamine → HCID 178433305, compound

Participants

Reaction Steps

A mixture of N-cyano-N'-[2-((4-methyl-5-imidazolyl)methylthio)-ethyl]-S-methylisothiourea (8.07 g) and histamine base (3.36 g) was heated for 3 hours at 100° and then for 3 hours at 130°-140°. The product was chromatographed on a column of silica gel with ethyl acetate/isopropyl alcohol (5:1 ) as eluent and crystallised by slow evaporation from isopropyl alcohol. Recrystallisation from water afforded the title compound, m.p. 170°-171°. (Found: C, 50.3; H, 6.2; N, 33.5; S, 9.7% C14H20N8S requires: C, 50.6; H, 6.1; N, 33.3; S, 9.7%).

Provenance & Evidence