反应详情

N-Cyano-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-S-methylisothiourea (5.4 g) and (2-aminoethyl)methylamine (25 ml) were mixed together and left for 15 hours at 20° C. Evaporation to dryness and azeotroping with acetonitrile to remove excess diamine gave a solid residue which was recrystallised from isopropanol to give the title compound (4.8 g), m.p. 146°-148° C. (Found: C, 48.7; H, 7.3; N, 32.9; S, 10.9% C12H21N7S requires: C, 48.8; H, 7.2; N, 33.2; S, 10.9%).

1. customEvaporation to dryness
2. customazeotroping with acetonitrile
3. customto remove excess diamine
4. customgave a solid residue which
5. customwas recrystallised from isopropanol