Water → HCID 18956023, compound

Participants

Reaction Steps

A mixture of p-methoxybenzyl glycinate hydrochloride (23.2 g., 0.1 mole), H2O (50 ml.), and EtOAc (150 ml.) is stirred vigorously with ice-bath cooling while an ice-cold, saturated aqueous solution of K2CO3 (25 ml.) is added. The aqueous phase is separated and extracted with more EtOAc (2 × 50 ml.). The combined EtOAc solution is dried with MgSO4, filtered, evaporated in vacuo, and stripped with PhH to provide p-methoxybenzyl glycinate (17.4 g.) as a pale yellow liquid.

Provenance & Evidence