Iodoethane → HCID 20321457, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1.07 g. of 3-(β-diethylaminoethyl)-4-phenyl-6-chloro-3,4-dihydro-2(1H)-quinazolinone in 20 ml. of dimethylformamide was added 0.13 g. of 64% sodium hydride, and the resulting mixture was heated with stirring at 60° C (bath temperature) for 1 hour. Thereafter, 0.94 g. of ethyl iodide was added thereto at room temperature, and the mixture was stirred at 100° C (bath temperature) for 4 hours. After cooling, the reaction mixture was poured into 100 ml. of water, extracted with chloroform, washed with water and dried over anhydrous sodium sulfate, and then the solvent was removed under reduced pressure to obtain colorless oily 1-ethyl-3-(β-diethylaminoethyl)-4-phenyl-6-chloro-3,4-dihydro-2(1H)-quinazolinone hydroiodide. This compound was crystallized from ethanol-petroleum benzine to give colorless fine crystals having a melting point of 198°-199° C (decomp.).

Provenance & Evidence