Methyl iodide → HCID 85857780, compound

HRID 866501Notes

Reaction equation

HRID 866501 reaction equation
[CH2:1]1[O:27][C:4]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[F:26])([C:5]2[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:6]=2[CH2:12]SC2C=CC=CC=2)[O:3][CH2:2]1.C[I:29]>>[CH2:1]1[O:27][C:4]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[F:26])([C:5]2[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:6]=2[CH2:12][I:29])[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 86733072HCID 86733072, compound

Product 1

HCID 85857780HCID 85857780, compound

Procedure

The starting material is obtained as follows: The solution of 10 g of 5-chloro-2'-fluoro-2-phenylmercaptomethyl-benzophenone ethylene ketal (Example 2) in 50 ml of methyl iodide is refluxed under nitrogen for 5 days. It is evaporated and the formed methyl phenyl tnioether distilled off at 60°/0.1 mm Hg, to yield the 5-chloro-2'-fluoro-2-iodomethyl-benzophenone ethylene ketal.

Workup

  1. customThe starting material is obtained
  2. customIt is evaporated
  3. distillationthe formed methyl phenyl tnioether distilled off at 60°/0.1 mm Hg

Sources & evidence

ORD record
ord-9f506deff680471b9ca916ec68b16c22
Source dataset
uspto-grants-1978_07
Patent number
US04099012

Reaction notes

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