HCID 178449506, compound → HCID 178449507, compound

HRID 866532Notes

Reaction equation

HRID 866532 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:9]([N:11]1[CH2:22][CH2:21][CH2:20][C@H:12]1[C:13]([NH:15][CH2:16][CH2:17][CH2:18][CH3:19])=[O:14])=[O:10])[CH2:3][C:4]1[N:8]=[CH:7][NH:6][CH:5]=1>O>[NH2:1][C@H:2]([C:9]([N:11]1[CH2:22][CH2:21][CH2:20][C@H:12]1[C:13]([NH:15][CH2:16][CH2:17][CH2:18][CH3:19])=[O:14])=[O:10])[CH2:3][C:4]1[N:8]=[CH:7][NH:6][CH:5]=1

Participants

3

Reactant 1

HCID 178449506HCID 178449506, compound

Product 1

HCID 178449507HCID 178449507, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Using 1.63 g. (0.004 M) of BOC-His-Pro-NHCH2CH2CH2CH3, the title compound is synthesized in the same manner as described in Example 3 (c) for the synthesis of the methyl-compound. Yield 1.16 g.; optical rotation [α]D21 -65.0° (c=0.60, in water); thin-layer chromatography Rf1 =0.62.

Sources & evidence

ORD record
ord-c41ad55ea6214c249ce0cdafba27fe5f
Source dataset
uspto-grants-1978_07
Patent number
US04100152

Reaction notes

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