HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 866538Generated: October 31, 2026
Cyanoacetic acid → 3-Amino-3,3-diphosphonopropanoic acid
https://huagongshe.com/reaction/866538
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cyanoacetic acid | HCID 9740 | — |
| Reactant | Phosphorous acid | HCID 107909 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 3-Amino-3,3-diphosphonopropanoic acid | HCID 20556515 | — |
Reaction Steps
A mixture of cyanoacetic acid (4.3 g, 0.5 mole), phosphorous acid (8.2 g, 0.1 mole), ISOPAR-M (20 g), and the wetting agents (0.25 g each) was heated at 165° C for 2 hours. The product was worked up with acetone to get yellow crystals of 1-amino-1,1-diphosphono-2-carboxy ethane, m.p. 255° C (decomposition), 55%, associated with traces of impurities.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04100167 |
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| Source dataset | uspto-grants-1978_07 |
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| ORD ID | ord-c6f4be4f1c3b4c00887c53a220298922 |
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| Source note | uspto-grants-1978_07 |
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