HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 866561Generated: October 29, 2026
Phenylacetyl chloride → 2-(3-Phenylacetamido-4-hydroxyphenyl)propionitrile
https://huagongshe.com/reaction/866561
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phenylacetyl chloride | HCID 7679 | — |
| Reactant | 2-(3-Amino-4-hydroxyphenyl)propanenitrile | HCID 12202636 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-(3-Phenylacetamido-4-hydroxyphenyl)propionitrile | HCID 54364252 | — |
Reaction Steps
Phenyl acetyl chloride (28.0 g.) was added over 20 minutes to a cooled stirred solution of 2-(3-amino-4-hydroxyphenyl) propionitrile (29.0 g.) in anhydrous pyridine (200 ml.) at 0°-3° C. After addition was complete, the mixture was heated at 100° C. for 1 hour. After evaporation under reduced pressure, 2-(3-phenylacetamido-4-hydroxyphenyl)propionitrile was isolated as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04100168 |
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| Source dataset | uspto-grants-1978_07 |
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| ORD ID | ord-1d3feb24f765494cbd144ef7f5a41f75 |
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| Source note | uspto-grants-1978_07 |
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