反应详情

In argon atmosphere, 2-diazo-3-oxo-6-heptenoic acid methyl ester (34 g, 0.187 mmol) was dissolved in benzene (300 ml). An acetyl acetone-copper complex (1 g) was added to the solution. The mixture was stirred for one night under refluxing. After cooling it, the solvent was distilled off under a reduced pressure. The residue was purified by a distillation to obtain 17.1 g of 2-oxo-bicyclo [3.1.0] hexane-1-carboxylic acid methyl ester. Yield: 60%. Boiling point: 83° to 85° C/0.3 mmHg.

1. additionAn acetyl acetone-copper complex (1 g) was added to the solution
2. temperatureunder refluxing
3. temperatureAfter cooling it
4. distillationthe solvent was distilled off under a reduced pressure
5. distillationThe residue was purified by a distillation