4-Fluorophenol → HCID 22767921, compound

HRID 866599Notes

Reaction equation

HRID 866599 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Cl[C:10]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][C:11]=1[CH:12]=[O:13].[OH-].[Na+]>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:10]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][C:11]=2[CH:12]=[O:13])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 97324-FluorophenolHCID 14798Sodium HydroxideHCID 729332-Chloro-5-nitrobenzaldehyde

Product 1

HCID 22767921HCID 22767921, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

448 G. of 4-fluoro-phenol and 742 g. of 2-chloro-5-nitro-benzaldehyde are added to a solution of 184 g. of sodium hydroxide in 7.4 liters of water. The mixture is then left to cool to room temperature. The precipitate is removed by filtration, washed carefully with water, and there is obtained 2-(4-fluoro-phenoxy)-5-nitro-benzaldehyde, having a melting point of 125°-126° C.

Workup

  1. waitThe mixture is then left
  2. customThe precipitate is removed by filtration
  3. washwashed carefully with water

Sources & evidence

ORD record
ord-88234cf375ce4d30b2ae29ecd6734372
Source dataset
uspto-grants-1978_07
Patent number
US04100173

Reaction notes

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