3-Chloro-1-propanol → 3-{4-[2-Chloro10,11-dihydro-dibenz[b,f]oxepin-10-yl]-1-piperazinyl}-1-propanol

HRID 866609Notes

Reaction equation

HRID 866609 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]2[O:6][C:7]3[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=3[CH:9]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)[CH2:10][C:4]=2[CH:3]=1.Cl[CH2:24][CH2:25][CH2:26][OH:27]>>[Cl:1][C:2]1[CH:22]=[CH:21][C:5]2[O:6][C:7]3[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=3[CH:9]([N:11]3[CH2:12][CH2:13][N:14]([CH2:24][CH2:25][CH2:26][OH:27])[CH2:15][CH2:16]3)[CH2:10][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 123133-Chloro-1-propanolHCID 227679431-[2-Chloro-10,11-dihydro-dibenz[b,f]oxepin-10-yl]-piperazine

Product 1

HCID 203151243-{4-[2-Chloro10,11-dihydro-dibenz[b,f]oxepin-10-yl]-1-piperazinyl}-1-propanol

Procedure

In an analogous manner to that described in Example 5, from 1-[2-chloro-10,11-dihydro-dibenz[b,f]oxepin-10-yl]-piperazine and 3-chloro-1-propanol, there is obtained 3-{4-[2-chloro-10,11-dihydro-dibenz[b,f]oxepin-10-yl]-1-piperazinyl}-1-propanol as an oil. The dihydrochloride, prepared in ethanol, melts at 206°-207° C (with decomposition).

Sources & evidence

ORD record
ord-c14d658aefb3478ebc05c32b67187dcb
Source dataset
uspto-grants-1978_07
Patent number
US04100173

Reaction notes

Loading…