3-(Trifluoromethyl)phenol → 4-Chloro-2-(3-trifluoromethyl-phenoxy)-benzoic acid

HRID 866618Notes

Reaction equation

HRID 866618 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4](I)[CH:3]=1.[F:12][C:13]([F:22])([F:21])[C:14]1[CH:15]=[C:16]([OH:20])[CH:17]=[CH:18][CH:19]=1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([O:20][C:16]2[CH:17]=[CH:18][CH:19]=[C:14]([C:13]([F:12])([F:21])[F:22])[CH:15]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 73763-(Trifluoromethyl)phenolHCID 1394524-Chloro-2-iodobenzoic acid

Product 1

HCID 227678684-Chloro-2-(3-trifluoromethyl-phenoxy)-benzoic acid

Procedure

In a manner analogous to that described in Example 1, 4-chloro-2-iodobenzoic acid is reacted with 3-trifluoromethyl-phenol, and there is obtained 4-chloro-2-(3-trifluoromethyl-phenoxy)-benzoic acid having a melting point of 146° C.

Sources & evidence

ORD record
ord-bcdd5aeb9d874aa0b1462016573f76db
Source dataset
uspto-grants-1978_07
Patent number
US04100173

Reaction notes

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