Hydroxyamine hydrochloride → HCID 136388414, compound

Participants

Reaction Steps

A solution of the compound of formula V, 5,6-dihydro-3,3-dimethyl-4,1-benzoxazonine-2,7(1H,3H)-dione (described in Example 1, 50 g), sodium acetate (37.5 g) and hydroxylamine hydrochloride (31.5 g) in ethanol (1,200 ml) is stirred at room temperature for two days. The precipitate is removed by filtration and the filtrate evaporated. Water and diethyl ether are added to the residue. The organic phase is separated, dried and evaporated. The residue is crystallized from ethanol to give 5,6-dihydro-3,3-dimethyl-4,1-benzoxazonin-2,7(1H,3H)-dione 7-oxime, mp 205°-206° C.

Provenance & Evidence