1-Phenethylamine, (-)- → HCID 22803897, compound

HRID 866688Notes

Reaction equation

HRID 866688 reaction equation
[Br:1]/[CH:2]=[C:3]1/[CH:4]([OH:11])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10]/1.C[C@H](N)C1C=CC=CC=1>>[Br:1]/[CH:2]=[C:3]1/[C@@H:4]([OH:11])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10]/1

Participants

3

Reactant 2

HCID 758181-Phenethylamine, (-)-HCID 70582708HCID 70582708, compound

Product 1

HCID 22803897HCID 22803897, compound

Procedure

This alcohol was resolved, as in the previous examples, by conversion to the half ester XXXIc and then to the salt with L-(-)-α-methylbenzylamine. Three recrystallizations of this salt from 2-propanol gave 37 g, mp 144°-145° C, αD = +36.0 (c 2.0, CH3OH).

Workup

  1. customThree recrystallizations of this salt from 2-propanol
  2. customgave 37 g, mp 144°-145° C, αD = +36.0 (c 2.0, CH3OH)

Sources & evidence

ORD record
ord-887721d003b14c0abe0bcb172f954488
Source dataset
uspto-grants-1978_07
Patent number
US04100353

Reaction notes

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